Negative Pressure Glove Box

Cleanroom equipment – Gloveboxes and Isolators

When should a glove box be used in negative pressure or a vacuum? A negative pressure glove box is a device for confining or recreating an atmosphere different from the ambient atmosphere in order to protect manual manipulation, the environment or operators. If it is used as safety equipment in various production processes, research applications or quality control, it can operate either under vacuum (negative pressure) or positive pressure. In order to choose the right equipment for your applications and project, you need to understand how it works.

Glove Box Operating Principle


The glove box is a closed, watertight and hermetic enclosure to separate an environment from the ambient conditions. To do this, it has a fully sealed compartment where the atmosphere can be controlled and monitored by means of built-in regulators. For glove boxes operating under gas, a purification system removes moisture and oxygen from the gas to make the process safe. The glove box also includes transparent sides equipped with handling gloves. These allow operators to handle items, products or substances without the risk of contamination or the spread of dangerous products in the environment. A transfer airlock allows the protected items to pass through without compromising containment.

Glove box operate under negative pressure or vacuum when the pressure inside its enclosure is lower than atmospheric pressure. This type of glove box is dedicated exclusively to the protection of operators and the environment. It uses a ventilation system with HEPA filters that uses ambient air from the room and extracts it to ducts after circulating through the enclosure. Thus, hazardous materials can neither come into contact with the operators nor spread in the environment. It is possible to monitor the chemical composition of the environment, gaseous emissions and leaks for maximum safety.

Examples of applications for a glove box under vacuum include: handling of hazardous pharmaceutical or chemical compounds, weighing and sampling operations, handling of pathogens or radioactive materials, reconditioning of CMR and toxic powders, powder dissolution, etc.


Which Negative Pressure Glove Box to Select?


Glove box specialists design standard or custom-made glove box models for the protection of operators and the environment. Jacomex is a world reference in this sector. Specialized in the design and manufacture of containment solutions for various sectors, it offers several vacuum glove boxes:




This glove box is a modular model under filtered neutral gas with autonomous purification unit. It is suitable for industrial, nuclear, pharmaceutical and advanced research applications, particularly processes requiring the integration of instrumentation, equipment and machinery.


G(Safe) Glove Box


This high-security glove box under filtered air enhances the safety of operators and the environment. It keeps the atmosphere under negative pressure and automatically triggers a safety flow response in case of a break in containment. It is also a modular model for more flexibility.


G(Iso) Isolator


This high security stainless steel isolator under filtered neutral gas is adapted to the high requirements of pharmaceutical and medical processes. It is custom designed and operates in vacuum under air/nitrogen. It is ideal to protect the operators and the environment during the analysis and weighing of active ingredients and CMR, quality controls, in the manufacture of surgical and dental implants.


G(Polym) Glove Box


This polymer glove box is a versatile model that can be used for both operator and product protection. It is available in standard sizes, but Jacomex also offers a custom-made design.

All Jacomex negative pressure glove boxes can be accessorized according to the requirements of each project.

The Negative Pressure Glove Boxe Range

Glove box designed for research and industry for all applications < 1PPM H2O – O2

Adjustable glove box under filtered air offering protection for the operator and / or the environment.

Multi-purpose glove box in polymer material: Corian, PMMA, PVC, PE …

High security isolator under neutral gas filtered in depression or overpressure under filtered atmosphere.

Get a Free Quote Without Obligation

Contact our commercial team to get a customized quote for a Jacomex glove box.

Our clients

Many customers from a variety of industries have trusted Jacomex to design and manufacture their glove boxes, insulators and air purification systems.

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01120 Dagneux – France

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All of our products are designed and manufactured in France